Document Detail


Placental weights of normal and aneuploid early human fetuses.
MedLine Citation:
PMID:  2798268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Placental and body weights were plotted for 252 normal human fetuses less than 600 gm and mean regressions and 95% prediction intervals were calculated. Placentas from 62 aneuploid fetuses were compared to these standards. Placenta to body weight ratios from 34 trisomy-21 fetuses were not reduced but those from 15 trisomy-18 fetuses were generally decreased. One of 5 trisomy-13 ratios was below the prediction interval. Among 7 triploid fetuses the ratios were above the normal interval in 3 and below normal in 4. Three of the triploids that were below were associated with a karyotype of 69,XXX and did not have hydatidiform degeneration. All 4 placentas with hydatidiform changes were abnormally large. All of the 7 triploids had 3-4 syndactyly and 3 had hydrocephalus.
Authors:
T H Shepard; J M FitzSimmons; A G Fantel; J Pascoe-Mason
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric pathology / affiliated with the International Paediatric Pathology Association     Volume:  9     ISSN:  0277-0938     ISO Abbreviation:  Pediatr Pathol     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-08     Completed Date:  1989-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8303527     Medline TA:  Pediatr Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  425-31     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine, University of Washington, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Chromosome Aberrations
Chromosome Disorders
Female
Fetus / cytology*
Humans
Karyotyping
Male
Organ Size
Placenta / anatomy & histology*
Sex Chromosome Aberrations
Statistics as Topic
Grant Support
ID/Acronym/Agency:
HD 00836/HD/NICHD NIH HHS; HD 12717/HD/NICHD NIH HHS
Comments/Corrections
Erratum In:
Pediatr Pathol 1990;10(1-2):305

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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