Document Detail

Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes.
MedLine Citation:
PMID:  21295850     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the utility of first-trimester 3D-placental volume and vascular flow indices in the prediction of adverse pregnancy outcomes.
METHODS: A prospective cohort study including women with singleton pregnancies seen between 11 and 14 weeks as part of a screening program for aneuploidy. Placental volume and vascularization indices were obtained using 3D power Doppler imaging and the VOCAL technique. Placental volume (PV), Vascularization Index (VI), Flow Index (FI) and Vascularization Flow Index (VFI) were calculated. The adverse pregnancy outcomes investigated include preeclampsia (PE), gestational hypertension (GH) and small for gestational age (SGA). The predictive ability of each variable was evaluated using receiver-operating characteristic (ROC) curves.
RESULTS: Of 388 women included, PE was seen in 30 (7.7%), GH in 37 (9.0%) and SGA in 31 (8.0%). Placental volume was not significantly different between the pregnancies with adverse outcomes and those without. The mean values of the VI and VFI were significantly lower in the pregnancies that developed PE but not in GH or SGA. The area under the ROC curve for the prediction of PE was 0.71, 0.69 and 0.70 for VI, FI and VFI, respectively.
CONCLUSION: The study confirms lower 3D power Doppler vascular flow indices in pregnancies that develop PE. The discriminatory ability of using these indices alone for predicting PE appears modest.
A O Odibo; K R Goetzinger; K M Huster; J K Christiansen; L Odibo; M G Tuuli
Publication Detail:
Type:  Journal Article     Date:  2011-02-04
Journal Detail:
Title:  Placenta     Volume:  32     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  2011-07-01     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Area Under Curve
Cohort Studies
Diabetes, Gestational / etiology*,  ultrasonography
Logistic Models
Placenta / blood supply*,  ultrasonography
Pre-Eclampsia / etiology*,  ultrasonography
Predictive Value of Tests
Pregnancy Trimester, First
Prospective Studies
ROC Curve
Ultrasonography, Doppler / methods
Ultrasonography, Prenatal / methods
Grant Support
T32 HD055172/HD/NICHD NIH HHS; T32 HD055172-02/HD/NICHD NIH HHS; UL1 RR024992-05/RR/NCRR NIH HHS

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