Document Detail

Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis.
MedLine Citation:
PMID:  21151528     Owner:  NLM     Status:  In-Data-Review    
Necrotizing enterocolitis (NEC) is a severe neonatal disease affecting particularly preterm infants. Its exact pathogenesis still remains unknown. In this study, we have compared the prevalence of vascular obstructive lesions in placentae of premature newborns which developed NEC and of a control group. We further compared separately the findings of placentae of infants of less than 30 weeks of gestation, the age group in which NEC occurs most frequently. We found signs of fetal vascular obstructive lesions in 65% of the placentae of preterm patients developing NEC, compared to only 17% of the placentae of preterm patients in the control group. In the age groups below 30 weeks of gestation, 58.5% of placentae of later NEC patients presented such lesions compared to 24.5% in the control group. The significant difference between NEC and control group suggests a strong association between fetal vascular obstructive lesions and NEC. Therefore, we propose that fetal vascular obstructive lesions might be considered as a risk factor for the development of NEC in premature infants.
Laure Dix; Matthias Roth-Kleiner; Maria-Chiara Osterheld
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Publication Detail:
Type:  Journal Article     Date:  2010-05-10
Journal Detail:
Title:  Pathology research international     Volume:  2010     ISSN:  2042-003X     ISO Abbreviation:  Patholog Res Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526292     Medline TA:  Patholog Res Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  838917     Citation Subset:  -    
Institute of Pathology, University of Lausanne, CH-1011 Lausanne, Switzerland.
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