Document Detail


Placental and vascular adaptations to exercise training before and during pregnancy in the rat.
MedLine Citation:
PMID:  22814667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although exercise during pregnancy is generally recommended and thought to be beneficial to mother and fetus, the nature of the adaptations to exercise during pregnancy and how they may be beneficial remain poorly understood. Recent studies suggest that exercise may stimulate expression of several cytoprotective and pro-angiogenic molecules such as heat shock proteins (HSP) and vascular endothelial growth factors (VEGF). We hypothesized that exercise training during pregnancy improves angiogenic balance, increases HSP expression, and improves endothelial function. Female rats were given access to an exercise wheel for 6 wk before and during pregnancy. On day 19 of pregnancy tissues were collected and snap frozen for later analysis. Western blots were performed in skeletal muscle and placenta. HSP 27 (3.7 ± 0.36 vs. 2.2 ± 0.38; P < 0.05), HSP 60 (2.2 ± 0.73 vs. 0.49 ± 0.08; P < 0.05), and HSP 90 (0.33 ± 0.09 vs. 0.11 ± 0.02; P < 0.05) were increased in the placentas of exercise-trained rats compared with sedentary controls. In addition, exercise training increased (P < 0.05) plasma free VEGF and augmented (P < 0.05) endothelium-dependent vascular relaxation compared with nonexercise control rats. The present data indicates chronic exercise training stimulates HSP expression in the placenta and that regular exercise training increases circulating VEGF in pregnant but not in nonpregnant rats. Although the present findings suggest that exercise before and during pregnancy may promote the expression of molecules that could attenuate placental and vascular dysfunction in complicated pregnancies, further studies are needed to determine the safety and effectiveness of exercise training as a therapeutic modality in pregnancy.
Authors:
Jeffrey S Gilbert; Christopher T Banek; Ashley J Bauer; Anne Gingery; Hans C Dreyer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-18
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  303     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2012-11-20     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R520-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Animals
Blood Pressure / physiology
Endothelium, Vascular / physiology
Female
Heart Rate / physiology
Heat-Shock Proteins / metabolism
Models, Animal
Muscle, Skeletal / blood supply,  metabolism
Neovascularization, Physiologic / physiology*
Physical Conditioning, Animal / physiology*
Placenta / physiology*
Pregnancy
Pregnancy, Animal / physiology*
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A / metabolism
Grant Support
ID/Acronym/Agency:
HL-114096/HL/NHLBI NIH HHS; K01 HD057332/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Vascular Endothelial Growth Factor A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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