| Placental transport of threonine and its utilization in the normal and growth-restricted fetus. | |
| | |
MedLine Citation:
|
PMID: 9176191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Placental transport and fetoplacental utilization of threonine (Thr) were compared at 130 +/- 1 days gestational age between seven control ewes (C) and six ewes in which intrauterine growth restriction (IUGR) had been induced by exposure to high ambient temperature from 33 +/- 1 to 112 +/- 2 days of gestation. The fluxes were measured using simultaneous intravenous infusions of L-[1-13C]Thr into the mother and L-[U-14C]Thr into the fetus. The IUGR group had less fetal weight (1.27 +/- 0.14 vs. 3.10 +/- 0.10 kg, P < 0.01) and placental weight (120 +/- 17 vs. 295 +/- 14 g, P < 0.01) than the C group. The direct flux of maternal Thr into the fetal systemic circulation was less in the IUGR fetuses, both relative to fetal weight (1.40 +/- 0.19 vs. 2.19 +/- 0.18 mumol.min-1.kg fetus-1, P = 0.0107) and placental weight (1.5 +/- 0.2 vs. 2.3 +/- 0.2 mumol.min-1.100 g placenta-1, P = 0.0187). In both groups, there was excretion of CO2 produced from fetal Thr. The rate of CO2 production from fetal plasma Thr carbon by fetus plus placenta was reduced in the IUGR group (1.50 +/- 0.23 vs. 2.86 +/- 0.32 mumol.min-1.kg fetus-1, P = 0.0065). We conclude that the flux of maternal Thr into the IUGR fetus is markedly reduced because of a reduction in placental mass and because of a weight-specific reduction in Thr placental transport. The reduced flux is routed into fetal Thr accretion via a decrease in fetal Thr oxidation. |
| | |
Authors:
|
A H Anderson; P V Fennessey; G Meschia; R B Wilkening; F C Battaglia |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 272 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-07-08 Completed Date: 1997-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E892-900 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport Body Weight Carbon Dioxide / blood Female Fetal Growth Retardation / metabolism* Fetus / anatomy & histology, metabolism Maternal-Fetal Exchange Organ Size Placenta / anatomy & histology, metabolism* Pregnancy Reference Values Sheep Threonine / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
DK-34914/DK/NIDDK NIH HHS; DK-48520/DK/NIDDK NIH HHS; HD-20761/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 72-19-5/Threonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Progesterone-induced changes in sleep in male subjects.
Next Document: Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction.