| Placental transport in pregnancy pathologies. | |
| | |
MedLine Citation:
|
PMID: 21543540 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The placenta is positioned between the maternal and fetal circulation and hence plays a key role in transporting maternal nutrients to the developing fetus. Fetal growth changes in the 2 most frequent pregnancy pathologies, gestational diabetes mellitus and fetal growth restriction, are predominantly characterized by an exaggerated and restricted fat accretion, respectively. Glucose, by its regulating effect on fetal insulin concentrations, and lipids have been strongly implicated in fetal fat deposition. Transplacental glucose flux is highly efficient and limited only by nutrient availability (flow-limited)-ie, driven by the maternal-fetal glucose concentration gradient and blood flow, with little, if any, effect of placental morphology, glucose consumption, and transporter expression. This explains why, despite changes in these determinants in both pathologies, transplacental glucose flux is unaltered. |
| | |
Authors:
|
Gernot Desoye; Martin Gauster; Christian Wadsack |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: - ISSN: 1938-3207 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Obstetrics and Gynaecology and the Institute of Cell Biology, Histology and Embryology; Medical University of Graz, Graz, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The OBELIX project: early life exposure to endocrine disruptors and obesity.
Next Document: Effect of dietary factors in pregnancy on risk of pregnancy complications: results from the Norwegia...