Document Detail


Placental transfer of tetanus-specific immunoglobulin G in Iranian mothers.
MedLine Citation:
PMID:  14694968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate placental transfer of anti-tetanus immunoglobulin (Ig)G antibodies in Iranian mothers. METHODS: Sera collected from 209 pregnant women and their paired infants were evaluated for tetanus-specific antibodies by a commercial enzyme-linked immunosorbent assay. RESULTS: In total, 15 (7.2%) out of 209 mothers and 12 (5.7%) out of 209 newborns were negative for anti-tetanus IgG. A highly significant correlation was observed between maternal and fetal anti-tetanus IgG (r = 0.80). The mean cord/maternal blood ratio of anti-tetanus IgG was 1.22 +/- 0.97. The mean cord/maternal blood ratio of anti-tetanus IgG in mothers with blood groups B+ and AB+ was lower than in mothers with other blood groups (p = 0.027). In addition, among mothers who had more than 0.5 IU/ml anti-tetanus IgG, a higher percentage of cases with cord/maternal blood ratio of < 1 was observed in carriers of blood groups B+ and AB+ compared to those with other blood groups (45.2% vs. 41.8%). Parity of more than 4 had a significant negative effect on both frequency of high positive sera and the mean of anti-tetanus IgG level in maternal and neonatal sera. CONCLUSIONS: A relatively high percentage of pregnant women were not immune against tetanus. It was also found that the main factors that affect infants' tetanus-specific IgG are maternal concentration of this immunoglobulin, parity and maternal blood group.
Authors:
A Samsami Dehaghani; M Doroudchi; A Ghaderi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  14     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-12-25     Completed Date:  2004-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System / immunology
Adult
Antibodies, Bacterial / blood*
Antibody Specificity*
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood / immunology
Humans
Immunoglobulin G / blood*
Infant, Newborn
Iran
Maternal-Fetal Exchange*
Parity
Pregnancy
Tetanus / immunology*
Chemical
Reg. No./Substance:
0/ABO Blood-Group System; 0/Antibodies, Bacterial; 0/Immunoglobulin G

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