| Placental transfer of stobadine in rabbits. | |
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MedLine Citation:
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PMID: 10576457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stobadine, a pyridoindole antioxidant, was investigated for its placental transfer and distribution in New Zealand white rabbits on the 27th day of gestation. The concentrations of stobadine were determined in maternal and foetal organs (plasma, brain, heart) at 30, 60, 120, and 360 minutes after oral administration of the drug in a dose of 5 mg/kg. The results obtained proved that after oral stobadine intake by rabbits at the stage of advanced pregnancy both maternal and foetal organs were under a certain drug level which could act protectively against oxidative stress--frequently occurring during late organogenesis, foetal stages and delivery, as well as during early postnatal development. |
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Authors:
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E Ujházy; M Dubovický; L Soltés; V Faberová; M Zemánek; A Gajdosík |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 65 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-12-09 Completed Date: 1999-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2011-4 Citation Subset: IM |
Affiliation:
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Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacokinetics* Brain / metabolism Carbolines / blood, pharmacokinetics* Female Fetus / metabolism Maternal-Fetal Exchange / physiology* Myocardium / metabolism Placenta / metabolism* Pregnancy Rabbits Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Carbolines; 17411-19-7/dicarbine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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