Document Detail


Placental transfer of ondansetron during early human pregnancy.
MedLine Citation:
PMID:  16584287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Nausea and vomiting are common conditions that occur during early pregnancy and can be disabling. Ondansetron had been used in pregnant women when treatment with conventional antiemetics has failed; however, the safety and tolerability of this relatively new antiemetic drug during pregnancy is still uncertain. The objective of this study was to quantify the placental transfer of ondansetron in the first trimester of human pregnancy. PATIENTS AND METHODS: This was a prospective, observational study. Forty-one patients who requested surgical termination of pregnancy at the first trimester were administered three doses of ondansetron 8 mg before surgery. Maternal venous blood, coelomic fluid, amniotic fluid and fetal tissue were collected from each patient for analysis of ondansetron by liquid chromatography-mass spectometry. RESULTS: Ondansetron was found in all samples. Drug concentration in fetal tissue was significantly higher than that in the amniotic fluid and similar to that in the coelomic fluid. The median (interquartile range) fetal/maternal ratio was 0.41 (0.31-0.52) and there were no significant correlations between ondansetron concentrations in each compartment and gestational age. CONCLUSIONS: A significant amount of ondansetron was present in all embryonic compartments. The developmental significance of this drug exposure requires further investigation, i.e. whole embryo culture.
Authors:
Shing-Shun N Siu; Matthew T V Chan; Tze-Kin Lau
Related Documents :
17140507 - Eradication of intra-amniotic streptococcus mutans in a woman with a short cervix.
12898867 - Zinc and copper in the human placenta membranes.
16202747 - The syndrome of amniotic fluid embolism: a potential contribution of bradykinin.
7053907 - Radioimmunoassay of thyroxine and 3,3',5'-triiodothyronine (reverse t3) in human amniot...
15956767 - Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune f...
12390867 - Increased production of bioactive lysophosphatidic acid by serum lysophospholipase d in...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  45     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. nelsonsiu@cuhk.edu.hk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / metabolism
Antiemetics / blood,  pharmacokinetics*
Body Fluids / metabolism
Female
Fetus / metabolism*
Humans
Maternal-Fetal Exchange*
Models, Biological
Ondansetron / blood,  pharmacokinetics*
Pregnancy
Pregnancy Trimester, First / metabolism*
Serotonin Antagonists
Chemical
Reg. No./Substance:
0/Antiemetics; 0/Serotonin Antagonists; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Population pharmacokinetics of heroin and its major metabolites.
Next Document:  The effects of food on the bioavailability of fenofibrate administered orally in healthy volunteers ...