Document Detail

Placental transfer of ondansetron during early human pregnancy.
MedLine Citation:
PMID:  16584287     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Nausea and vomiting are common conditions that occur during early pregnancy and can be disabling. Ondansetron had been used in pregnant women when treatment with conventional antiemetics has failed; however, the safety and tolerability of this relatively new antiemetic drug during pregnancy is still uncertain. The objective of this study was to quantify the placental transfer of ondansetron in the first trimester of human pregnancy. PATIENTS AND METHODS: This was a prospective, observational study. Forty-one patients who requested surgical termination of pregnancy at the first trimester were administered three doses of ondansetron 8 mg before surgery. Maternal venous blood, coelomic fluid, amniotic fluid and fetal tissue were collected from each patient for analysis of ondansetron by liquid chromatography-mass spectometry. RESULTS: Ondansetron was found in all samples. Drug concentration in fetal tissue was significantly higher than that in the amniotic fluid and similar to that in the coelomic fluid. The median (interquartile range) fetal/maternal ratio was 0.41 (0.31-0.52) and there were no significant correlations between ondansetron concentrations in each compartment and gestational age. CONCLUSIONS: A significant amount of ondansetron was present in all embryonic compartments. The developmental significance of this drug exposure requires further investigation, i.e. whole embryo culture.
Shing-Shun N Siu; Matthew T V Chan; Tze-Kin Lau
Related Documents :
3126357 - Amniotic fluid propionylcarnitine in methylmalonic aciduria.
7400917 - Immune complexes in the sera and amniotic fluids of human pregnancy.
3524237 - Limitations of using maximum vertical pocket and other sonographic evaluations of amnio...
16856817 - Protein c, protein s, and thrombomodulin in amniotic fluid. a preliminary study.
22400417 - Anesthetic management of a patient undergoing an ex utero intrapartum treatment (exit) ...
8530657 - Pregnancy results from a vibrator application, electroejaculation, and a vas aspiration...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  45     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / metabolism
Antiemetics / blood,  pharmacokinetics*
Body Fluids / metabolism
Fetus / metabolism*
Maternal-Fetal Exchange*
Models, Biological
Ondansetron / blood,  pharmacokinetics*
Pregnancy Trimester, First / metabolism*
Serotonin Antagonists
Reg. No./Substance:
0/Antiemetics; 0/Serotonin Antagonists; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Population pharmacokinetics of heroin and its major metabolites.
Next Document:  The effects of food on the bioavailability of fenofibrate administered orally in healthy volunteers ...