Document Detail


Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates.
MedLine Citation:
PMID:  12683413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal antibodies may protect the fetus and neonate against severe forms of CMV-caused disease, therefore this study investigated the efficiency of the placental transfer of naturally acquired, maternal total anti-cytomegalovirus (CMV) IgG and neutralizing antibodies at different gestational ages. The study was conducted on 182 healthy CMV-seropositive Brazilian mothers and their 196 infants who were not infected congenitally with CMV, as determined by CMV detection in urine. The study groups were composed of 44 infants aged 28-30 weeks; 51 infants aged 31-33 weeks; 62 infants aged 34-36 weeks, and 39 infants of gestational age > or = 37 weeks. Quantitative detection of total CMV IgG was carried out using EIA and virus neutralizing titers were determined by a microneutralization assay in sera from mothers and infants. CMV IgG levels and neutralizing titers of the infants correlated with maternal levels (r=0.873 and r=0.841, respectively). The efficiency of placental transfer of these antibodies was enhanced significantly as gestation progressed until 34-36 weeks, when values similar to those of full-term infants (90-100%) were found. Transfer ratios were significantly higher for neutralizing compared to total CMV IgG antibodies at gestational age 31-33 weeks (100% vs. 84%, respectively) and at gestational age 28-30 weeks (75% vs. 60%, respectively). We conclude that placental transfer of naturally acquired maternal CMV neutralizing and total CMV IgG antibodies are similarly efficient above 34 weeks of gestational age. At less than 34 weeks of gestational age, transfer of neutralizing antibodies may be favored and these antibodies reach the neonatal serum of 99% of these premature infants.
Authors:
Marisa Márcia Mussi-Pinhata; Patrícia Cristina Gomes Pinto; Aparecida Yulie Yamamoto; Klara Berencsi; Cleonice Barbosa Sandoval de Souza; Mauro Andrea; Geraldo Duarte; Salim Moyses Jorge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  69     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. mmmpinha@fmrp.usp.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood,  immunology*
Cytomegalovirus / immunology*,  isolation & purification
Cytomegalovirus Infections / immunology,  virology
Female
Humans
Immunity, Maternally-Acquired*
Immunoglobulin G / blood,  immunology
Infant
Infant, Newborn
Infant, Premature / immunology*
Male
Neutralization Tests
Placenta / immunology*
Pregnancy
Pregnancy Complications, Infectious / immunology,  virology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

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