Document Detail

Placental transfer of local anesthetics.
MedLine Citation:
PMID:  7039931     Owner:  NLM     Status:  MEDLINE    
All the presently used local anesthetic agents in the increasingly popular modalities of obstetric regional anesthesia cross the placenta readily, governed only by two factors that the anesthesiologist has any control over (1) dosage and timing of doses and (2) uterine blood flow as it relates to the development of fetal acidosis. Uptake of a given dose of local agent from the epidural or caudal spaces may be limited with the addition of epinephrine to some extent with some drugs, but this is of little real value in the two safest drugs--bupivacaine and 2-chloroprocaine. At the doses and in the manner presently recommended, fetal intoxication with local anesthetic agent during maternal epidural analgesia should not occur in the absence of either direct intravascular injection, severe maternal hepatic disorder, marked fetal prematurity or postmaturity. The usual precautions in the exercise of regional anesthesia when applied to obstetrics render it very safe, if not the safest form of anesthesia-analgesia available.
D A Yurth
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  9     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-28     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium
Anesthesia, Obstetrical
Anesthetics, Local / administration & dosage,  metabolism*
Infant, Newborn
Maternal-Fetal Exchange*
Metabolic Clearance Rate
Placenta / blood supply,  metabolism
Protein Binding
Regional Blood Flow / drug effects
Uterus / blood supply
Reg. No./Substance:
0/Anesthetics, Local; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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