| Placental transfer of dexamethasone in near-term sheep. | |
| | |
MedLine Citation:
|
PMID: 551118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The placental transfer of 3H-dexamethasone was studied in six near-term sheep. The placental clearance of 3H-dexamethasone was 18.8 +/- 3.5 ml/min per kg of fetal weight. The clearance of dexamethasone by the fetal tissues was 9.3 +/- w.5 ml/min per kg. The maximum placental clearance was 285 +/- 24 ml/min and the degree of diffusion limitation to the placental transfer of dexamethasone was 78 +/- 4%. The placental transfer of dexamethasone is therefore limited primarily by the nature of the placental barrier. |
| | |
Authors:
|
D F Anderson; M K Stock; J H Rankin |
Related Documents
:
|
18061258 - Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complica... 20028358 - Ethanol-induced oxidative stress and mitochondrial dysfunction in rat placenta: relevan... 920768 - Oxytocinase and human placental lactogen for the prediction of intrauterine growth reta... 17113148 - Placental diversity in malagasy tenrecs: placentation in shrew tenrecs (microgale spp.)... 3793448 - Biocidal control of legionellae. 7520988 - Dominant lethal effects after inhalation exposure to 1,3-butadiene. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of developmental physiology Volume: 1 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1979 Dec |
Date Detail:
|
Created Date: 1980-11-20 Completed Date: 1980-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 431-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dexamethasone / blood* Female Fetal Blood / metabolism Kinetics Maternal-Fetal Exchange* Placenta / metabolism* Pregnancy Protein Binding Sheep / physiology* |
| Chemical | |
Reg. No./Substance:
|
50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glucose transfer across the intact guinea-pig placenta.
Next Document: Demonstration of a quiescent period for feeding controls in the developing rat.