Document Detail


Placental transfer of Zidovudine in first trimester of pregnancy.
MedLine Citation:
PMID:  16199642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Zidovudine is one of the most common antiretroviral drugs used to prevent vertical transmission of human immunodeficiency virus. However, it is not recommended for use in the first trimester of pregnancy because of reservations about its potential teratogenicity during the organogenesis phase. The objective of this study was to investigate the placental transfer of zidovudine in the first trimester of human pregnancy. METHODS: Twenty-six pregnant women were given 2 oral doses of zidovudine (200 mg) before first trimester surgical termination of pregnancy. Maternal blood, fetal tissue, and coelomic and amniotic fluid were collected for drug analysis. RESULTS: Zidovudine was detected in all samples of maternal serum and fetal tissue but present in only 7 samples of amniotic and coelomic fluid. Zidovudine concentration in fetal tissue was similar to that of maternal serum. The median fetal/maternal ratio was 0.92 and was not associated with gestational age (r = 0.03, P = .89). CONCLUSION: Zidovudine crossed the first trimester human placenta readily and achieved the level of maternal serum rapidly. Patients who choose to take zidovudine in first trimester of pregnancy should be counseled about the potential fetal effects.
Authors:
Shing-Shun Siu; John Hok-Keung Yeung; Man-Wah Pang; Pui Yu Chiu; Tze Kin Lau
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  106     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-12-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  824-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. nelsonsiu@cuhk.edu.hk
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MeSH Terms
Descriptor/Qualifier:
Abortion, Legal
Adolescent
Adult
Anti-HIV Agents / pharmacokinetics*
Female
Fetus / metabolism*
Humans
Maternal-Fetal Exchange*
Middle Aged
Placenta / metabolism*
Pregnancy
Pregnancy Trimester, First / metabolism*
Pregnancy, Unwanted / metabolism
Zidovudine / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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