Document Detail


Placental to fetal transfer of mercury and fetotoxicity.
MedLine Citation:
PMID:  12498319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mercury vapor is known penetrate the placental barrier more easily than inorganic mercury. A relative amount of mercury accumulates in the fetus after exposure of pregnant animals to mercury vapor. Mercury concentration in fetal organs is much lower than that in maternal organs except the liver, and fetal liver shows significantly higher mercury concentrations than maternal liver. In fetal liver, a substantial portion of mercury is bound to metallothionein (MT), which plays an important role as a reservoir of mercury during the prenatal period. The mercury retained in fetal liver is redistributed to other organs, such as the brain and kidney, with diminishing MT levels during postnatal development. Consequently, an increase in mercury concentration in the brain and kidney of the neonate is observed. In studies on animal offspring in utero exposed to mercury vapor, behavioral changes, such as radial arm maze, morris maze and lever-press durations, are observed when the levels of mercury vapor exceed the threshold limit value (TLV).
Authors:
Minoru Yoshida
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  196     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-05-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
Affiliation:
Department of Chemistry, St Marianna University School of Medicine, Kawasaki 216-8511, Japan. m2yosida@marianna-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Diseases / chemically induced*
Gases / metabolism
Humans
Liver / drug effects,  embryology,  metabolism
Maternal-Fetal Exchange / physiology*
Mercury / pharmacokinetics*,  toxicity*
Metallothionein / pharmacology
Placenta / metabolism*
Pregnancy
Tissue Distribution
Chemical
Reg. No./Substance:
0/Gases; 7439-97-6/Mercury; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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