| Placental phenotypes of intrauterine growth. | |
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MedLine Citation:
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PMID: 16183820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of alterations in placenta structure and function which leads to IUGR. We speculate that the alterations in the human placenta can also be grouped into patterns, or phenotypes, that are associated with specific patterns of fetal growth. Identifying the placental phenotypes of different fetal growth patterns will improve the ability of clinicians to recognize high-risk patients, of laboratory scientists to disentangle the complexities of IUGR, and of public health teams to target interventions aimed at ameliorating the long-term adverse effects of inadequate intrauterine growth. |
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Authors:
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Colin P Sibley; Mark A Turner; Irene Cetin; Paul Ayuk; C A Richard Boyd; Stephen W D'Souza; Jocelyn D Glazier; Susan L Greenwood; Thomas Jansson; Theresa Powell |
Publication Detail:
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Type: Journal Article; Review Date: 2005-09-23 |
Journal Detail:
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Title: Pediatric research Volume: 58 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2006-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 827-32 Citation Subset: IM |
Affiliation:
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Division of Human Development, Acadamic Unit of Child Health, The Medical School, University of Manchester, St. Mary's Hospital, Manchester M13 OJH, UK. colin.sibley@manchester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetal Development* Fetal Growth Retardation* Humans Maternal-Fetal Exchange Mice Phenotype Placenta / anatomy & histology, blood supply, physiology* Pregnancy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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