Document Detail


Placental phenotypes of intrauterine growth.
MedLine Citation:
PMID:  16183820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of alterations in placenta structure and function which leads to IUGR. We speculate that the alterations in the human placenta can also be grouped into patterns, or phenotypes, that are associated with specific patterns of fetal growth. Identifying the placental phenotypes of different fetal growth patterns will improve the ability of clinicians to recognize high-risk patients, of laboratory scientists to disentangle the complexities of IUGR, and of public health teams to target interventions aimed at ameliorating the long-term adverse effects of inadequate intrauterine growth.
Authors:
Colin P Sibley; Mark A Turner; Irene Cetin; Paul Ayuk; C A Richard Boyd; Stephen W D'Souza; Jocelyn D Glazier; Susan L Greenwood; Thomas Jansson; Theresa Powell
Publication Detail:
Type:  Journal Article; Review     Date:  2005-09-23
Journal Detail:
Title:  Pediatric research     Volume:  58     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2006-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  827-32     Citation Subset:  IM    
Affiliation:
Division of Human Development, Acadamic Unit of Child Health, The Medical School, University of Manchester, St. Mary's Hospital, Manchester M13 OJH, UK. colin.sibley@manchester.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Development*
Fetal Growth Retardation*
Humans
Maternal-Fetal Exchange
Mice
Phenotype
Placenta / anatomy & histology,  blood supply,  physiology*
Pregnancy

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