Document Detail


Placental pathology and abnormal fetal heart rate patterns in gestational diabetes.
MedLine Citation:
PMID:  2813198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants of diabetic mothers are considered to be at increased risk of fetal distress. We suggest that umbilical vasculitis is strongly associated with abnormal fetal rate patterns, which indicate fetal tissue hypoxia even in the absence of clinical evidence of intrapartum infection. In the present series, 132 term deliveries with Class A diabetes mellitus were compared with 159 uncomplicated term deliveries. Umbilical vasculitis and gestational age greater than 281 days were both highly correlated with abnormal fetal heart rate patterns in diabetic pregnancies (p less than 0.001). These effects were shown to be independent by multiple logistic regression. There was no difference in mean birthweight between infants of diabetic mothers and those of uncomplicated pregnancies, but infants of diabetic mothers had heavier placentas (p less than 0.01). These data further support our hypothesis that umbilical vasculitis may affect umbilical hemodynamics and predispose to development of fetal heart rate patterns.
Authors:
C M Salafia; L Silberman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pathology / affiliated with the International Paediatric Pathology Association     Volume:  9     ISSN:  0277-0938     ISO Abbreviation:  Pediatr Pathol     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8303527     Medline TA:  Pediatr Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  513-20     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Danbury Hospital, CT 06810.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Infections / complications
Chorioamnionitis / pathology
Female
Heart Rate, Fetal*
Humans
Infant, Newborn
Placenta / pathology*
Pregnancy
Pregnancy Complications, Infectious / pathology
Pregnancy in Diabetics / pathology*,  physiopathology
Umbilical Cord / pathology
Vasculitis / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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