Document Detail

Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios.
MedLine Citation:
PMID:  19194718     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the placental pathologies and perinatal outcomes in fetal growth restriction (FGR) pregnancies with and without oligohydramnios. METHODS: A retrospective cohort study, comparing placental findings in all singleton deliveries with FGR. RESULTS: Macroscopic placental findings were available for 1,104 singleton FGR pregnancies. A total of 397 placentas were microscopically examined; of which 89 placentas were of FGR neonates who had oligohydramnios. No significant differences in placental vascular mal-perfusion were found between pregnancies with and without oligohydramnios (69.3 vs. 74.3%; P = 0.357). Likewise, no significant differences were noted between the groups regarding diffuse villous fibrosis (10.1 vs. 4.9%; P = 0.573), and amnion cell metaplasia (65.9 vs. 64.3%; P = 0.779). Cases of FGR complicated with oligohydramnios had significantly higher rates of perinatal mortality (9.9 vs. 5.9%; P = 0.028), preterm deliveries (34.9 +/- 3.4 vs. 35.4 +/- 3.1 weeks of pregnancy; P = 0.041), and lower birth weight (1,737 +/- 542 vs. 1,845 +/- 467 g; P = 0.002) compared to FGR without oligohydramnios. CONCLUSIONS: Oligohydramnios is a significant risk factor for adverse perinatal outcome in FGR pregnancies; nevertheless, no significant differences in placental pathologies were noted.
Liat Apel-Sarid; Amalia Levy; Gershon Holcberg; Eyal Sheiner
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-02-05
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  280     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2010-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  IM    
Department of Pathology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel.
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MeSH Terms
Cohort Studies
Fetal Growth Retardation / pathology*
Infant, Newborn
Oligohydramnios / pathology*
Placenta / pathology*
Retrospective Studies
Young Adult

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