Document Detail

Placental pathologic conditions in anticardiolipin antibody positive women whose infants had congenital heart defects.
MedLine Citation:
PMID:  8866295     Owner:  NLM     Status:  MEDLINE    
Anticardiolipin antibodies (ACLA) are present in 10% of women with recurrent pregnancy loss. Other associations with ACLA are arterial and venous thrombosis, cerebral infarction, pulmonary hypertension, preterm delivery, and fetal growth retardation. A previous prospective study of infants of mothers with positive ACLA identified an increased incidence of congenital heart disease in this population. As a follow-up, the placentas of the initial 40 ACLA-positive patients were studied to determine whether there was an increased incidence of infarct or thrombosis compared with that in control subjects matched for maternal age and gestational age within the same 2-year period. The age of ACLA-positive mothers was 30 +/- 5 years versus 29 +/- 5 years in the ACLA-negative mothers. Gestational age was 37 +/- 2 weeks in both groups; placental weight was 553 +/- 169 gm in the ACLA-positive group versus 593 +/- 117 gm in the ACLA-negative group. The birth weight was 2972 +/- 709 gm in infants of ACLA-positive mothers and 2920 +/- 674 gm in infants of ACLA-negative mothers. There was no statistically significant difference between the two groups in gestational age, maternal disease, placental histologic findings, placental weight, type of delivery, or type of ACLA. Twenty-seven ACLA-positive women were receiving prednisone. Chi square analysis showed the ACLA-positive mothers to have more spontaneous abortions (p = 0.02) and to have more children with congenital heart disease (5 ventricular septal defects and 2 atrial septal defects) (p = 0.006). In summary, infants born with congenital heart defects in women positive for ACLA did not have significant placental pathologic conditions when compared with control infants.
A Kowal-Vern; S G Fisher; J Muraskas; M A Jandreski; J G Gianopoulos; A Husain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  16     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-71     Citation Subset:  IM    
Department of Pathology, Loyola University Medical Center, Maywood, Ill 60153, USA.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Antibodies, Anticardiolipin / analysis*
Chi-Square Distribution
Fetal Diseases / etiology*
Heart Defects, Congenital / epidemiology*,  etiology
Infant, Newborn
Logistic Models
Placental Insufficiency / complications,  drug therapy,  immunology*
Prednisone / therapeutic use
Pregnancy Complications / physiopathology*
Pregnancy Outcome*
Prenatal Care
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Anticardiolipin; 53-03-2/Prednisone

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