Document Detail


Placental-ovarian relationship in the control of testosterone secretion in the rat.
MedLine Citation:
PMID:  3658926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both ovaries and placentae of rats produce androgen in the second half of pregnancy. The objectives of this investigation were to determine whether the pituitary controls both ovarian and placental secretion of testosterone, to find out whether ovarian secretion of testosterone is maintained by the placenta, and to examine whether levels of testosterone produced by the ovaries and placentae depend upon the number of placentae present. Pregnant rats were hypophysectomized with or without hysterectomy in one experiment, and hypophysectomized with or without partial hysterectomy leaving one placenta in situ in another experiment. Testosterone output by the placenta(e) or the ovary was quantified. The results suggest that placental secretion of testosterone is independent of the pituitary between days 12 and 18 of pregnancy, reduction in placental number causes the remaining placenta to compensate by increasing its testosterone output, and ovarian secretion of testosterone may be under placental control between days 12 and 18 of pregnancy.
Authors:
R Sridaran; G Gibori
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Placenta     Volume:  8     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1987 May-Jun
Date Detail:
Created Date:  1987-11-18     Completed Date:  1987-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
Affiliation:
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310-1495.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Hysterectomy
Ovary / secretion*
Pituitary Gland / physiology
Placenta / anatomy & histology,  secretion*
Pregnancy
Rats
Rats, Inbred Strains
Testosterone / secretion*
Grant Support
ID/Acronym/Agency:
HD-11119/HD/NICHD NIH HHS; HD-17867/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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