| Placental α-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies. | |
| | |
MedLine Citation:
|
PMID: 21475966 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: We evaluated the performance of the placental alpha-microglobulin-1 immunoassay (AmniSure(®), AT) in cervicovaginal secretions in patients with uncertain rupture of membranes (ROM) and investigated the influence of the examiners experience. METHODS: This prospective cohort study was performed in pregnant women (17-42 weeks of gestation) with signs of possible ROM. Evaluation included clinical assessment, examination for cervical leakage, Nitrazine test and measurement of the amniotic fluid index by ultrasound and AT. ROM occurrence was based on review of the medical records after delivery. RESULTS: 199 women were included. AT had a sensitivity of 94.4%; specificity of 98.6%; positive predictive value, 96.2%; negative predictive value, 98.0%. Clinical assessment showed a sensitivity of 72.2%; specificity of 97.8%; positive predictive value, 92.9%; negative predictive value, 90.6%. AT was more sensitive for diagnosing ROM (p = 0.00596) compared to clinical assessment, independent of the examiners experience. Furthermore, the sole use of AT reduced costs by 58.4% compared to clinical assessment. CONCLUSIONS: AT was more sensitive compared to clinical assessment, independent of the examiners experience and gestational age. Our data extend its use in patients with uncertain ROM. Moreover, AT seems to be a cost-effective approach in the assessment of these patients. |
| | |
Authors:
|
Ariane Birkenmaier; Jean-Jacques Ries; Jens Kuhle; Nicole Bürki; Olav Lapaire; Irene Hösli |
Related Documents
:
|
2903806 - First-trimester diagnosis of metachromatic leucodystrophy. 15021886 - Nedd8 on cullin: building an expressway to protein destruction. 15070516 - Norfloxacin-loaded chitosan sponges as wound dressing material. 2044706 - Development and hormonal control of thioredoxin and the thioredoxin-reductase system in... 17712646 - Precision, consistency, and reproducibility of blood pressure in diabetic and non-diabe... 7187266 - Effect of factors related to the recipient and insemination characteristics on the succ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: - ISSN: 1432-0711 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Obstetrics and Gynaecology, University Hospital Basel, University of Basel, Spitalstr. 21, 4031, Basel, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal diagnosis of OEIS (omphalocele, bladder exstrophy, imperforate anus, clubfeet) variant asso...
Next Document: Maize csmd1 exhibits pre-meiotic somatic and post-meiotic microspore and somatic defects but sustain...