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Placental mesenchymal dysplasia presenting as a twin gestation with complete molar pregnancy.
MedLine Citation:
PMID:  21768849     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: : Placental mesenchymal dysplasia is a rare abnormality characterized by placentomegaly, grapelike cystic vesicles, and villous hyperplasia. The clinical and ultrasonographic presentation may mimic molar pregnancy, provoking incorrect diagnoses and unnecessary therapeutic interventions.
CASE: : A 36-year-old nulliparous woman presented for prenatal ultrasonography that indicated the presence of one gestational sac containing both fetus and cystic mass, concerning for partial molar pregnancy. Amniocentesis returned a 46,XX karyotype, suggesting a twin gestation with complete mole. The patient was monitored closely and, because of fetal growth restriction, was induced successfully at term and delivered a healthy newborn. Histopathologic findings of the placenta were consistent with placental mesenchymal dysplasia.
CONCLUSION: : Although placental mesenchymal dysplasia is often confused with molar pregnancy, it is important to consider both in a differential to avoid inappropriate treatments.
Authors:
Roman Starikov; Randi Goldman; Don S Dizon; Stefan Kostadinov; Stephen Carr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  118     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  AIM; IM    
Affiliation:
From the Division of Maternal-Fetal Medicine, the Program in Women's Oncology, and the Department of Pathology, Women & Infants Hospital, Providence, Rhode Island; the Departments of Obstetrics-Gynecology and Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island; and Albany Medical College, Albany, New York.
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