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Placental markers of folate-related metabolism in preeclampsia.
MedLine Citation:
PMID:  21690209     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Etiology and degree of clinical symptoms of preeclampsia depend on genotypic and phenotypic maternal and trophoblast factors, and elevated levels of plasma homocysteine (Hcy) are one of the pathogenetic factors of preeclampsia. To assess the impact of the folate-related metabolism, we characterized the indices of this metabolism in 40 samples from uncomplicated term placentas and 28 samples from preeclamptic pregnancies by quantifying the total content of folate, methionine, Hcy and related cysteine and glutathione in compliance with the 677 C/T genotype of methylene tetrahydrofolate reductase (MTHFR). The prevalence of MTHFR genotypes was not significantly different between the two groups. The polymorphism of MTHFR was not connected unambiguously with the content of total placental methionine, Hcy and related cysteine and glutathione either in uncomplicated or in complicated pregnancies. By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease of the methionine content, a trend towards increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e. g. positive relation between Hcy vs. cysteine and folate vs. glutathione, and negative relation between folate vs. Hcy and both Hcy and cysteine vs. glutathione. We demonstrated the expression of cystathionine-β-synthase in human placenta at term by RT-PCR and Western-blot analysis, for the first time confirmed its catalytic activity and the accumulation of cysteine and cystathionine-β-synthase in placental explants cultivated in the presence of elevated Hcy concentrations. We suggest that disturbance in placental folate-related metabolism may be one of the pathogenetic factors in preeclampsia.
Authors:
Csilla Mislanova; Olga Martsenyuk; Berthold Huppertz; Maria Yurievna Obolenskaya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-20
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
C Mislanova, Laboratory of Chromatographic Methods,, Slovak Medical University, Bratislava, Slovakia.
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