| Placental mTOR links maternal nutrient availability to fetal growth. | |
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MedLine Citation:
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PMID: 19143650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction), and recent experimental evidence suggests that these changes contribute directly to the restricted fetal growth. We have shown that mTOR regulates the activity of the placental L-type amino acid transporter system and that placental mTOR activity is decreased in IUGR. The present review summarizes the emerging evidence implicating placental mTOR signalling as a key mechanism linking maternal nutrient and growth factor concentrations to amino acid transport in the human placenta. Since fetal growth is critically dependent on placental nutrient transport, placental mTOR signalling plays an important role in the regulation of fetal growth. |
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Authors:
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Sara Roos; Theresa L Powell; Thomas Jansson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 37 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-02-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 295-8 Citation Subset: IM |
Affiliation:
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Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, P.O. Box 432, SE-405 30 Gothenburg, Sweden. sara.roos@gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetal Development* Food* Humans Maternal-Fetal Exchange* Placenta / enzymology* Pregnancy Protein Kinases / metabolism* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases; EC 2.7.1.-/mTOR protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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