Document Detail

Placental infection with Chlamydia pneumoniae and intrauterine growth restriction.
MedLine Citation:
PMID:  14522419     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The concept that low birth weight infants are more predisposed to coronary artery disease (CAD) in adulthood has been studied extensively. Although many infectious agents have been associated with intrauterine growth restriction (IUGR), Chlamydia pneumoniae an organism implicated in CAD has not been investigated. It was our aim to assess whether C. pneumoniae DNA is present in placental tissue and whether its detection is associated with IUGR. METHODS: Fifty-nine pregnant women were studied: 32 women had an uncomplicated pregnancy with no antenatal or post-natal evidence of IUGR. Twenty-seven women had pregnancies with ultrasonographically demonstrated IUGR, defined as foetal abdominal circumference measuring less than 2 S.D.s from the mean for gestational age. At the time of delivery, maternal blood and placental tissue samples were obtained. Placental samples were taken from four sites centrally and peripherally on the maternal and foetal side of the placentas and tested by nested polymerase chain reaction for C. pneumoniae DNA. IgG antibodies to C. pneumoniae were measured using microimmunfluorescence. RESULTS: C. pneumoniae DNA was detected in 44% of the placental tissue but there was no difference in the prevalence of bacterial DNA between the control and the low birth weight group (P=0.58). Additionally C. pneumoniae seropositivity did not differ between the index and control groups (78 vs. 70%, P=0.44). CONCLUSIONS: C. pneumoniae is present in placental tissue. Its presence however does not correlate with IUGR. Similarly, maternal C. pneumoniae seropositivity is not related to low birth weight. Thus C. pneumoniae infection is unlikely to play a role in the pathogenesis of IUGR.
Christina Baboonian; David A Smith; David Shapland; Gavin Arno; Behnam Zal; Julius Akiyu; Juan Carlos Kaski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  60     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-02     Completed Date:  2003-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK.
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MeSH Terms
Antibodies, Bacterial / analysis,  blood
Case-Control Studies
Chlamydia Infections / complications*,  diagnosis
Chlamydophila pneumoniae*
DNA, Bacterial / analysis
Fetal Growth Retardation / microbiology*,  ultrasonography
Immunoglobulin G / analysis
Immunohistochemistry / methods
Infant, Low Birth Weight
Infant, Newborn
Placenta Diseases / microbiology*
Polymerase Chain Reaction / methods
Ultrasonography, Prenatal
Reg. No./Substance:
0/Antibodies, Bacterial; 0/DNA, Bacterial; 0/Immunoglobulin G

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