Document Detail


Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy.
MedLine Citation:
PMID:  19689253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gestational diabetes mellitus (GDM) and pre-gestational diabetes are known to pose risks to the mother and developing fetus, often related to abnormal fetal growth. One potential mediator of maternal effects on fetal growth is Placental Growth Hormone (PGH). PGH is produced by the syncytiotrophoblast and found predominantly in the maternal circulation. It progressively replaces pituitary growth hormone (hGH) in the human maternal circulation from mid-gestation onwards, peaking towards term. PGH appears to be an important potential regulator of maternal insulin resistance in human pregnancy and may influence fetal growth both by modifying substrate availability and through paracrine actions in the placental bed. The details of PGH regulation remain relatively poorly understood, but current evidence does suggest a central role in growth restricted pregnancies. There is currently less evidence of a pathophysiologic role in production of the macrosomic fetal phenotype commonly seen in response to hyperglycaemia, although our recent in vitro studies do raise the possibility of feto-placental feedback as a mechanism of growth modulation.
Authors:
H D McIntyre; W Zeck; A Russell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reviews     Volume:  5     ISSN:  1875-6417     ISO Abbreviation:  Curr Diabetes Rev     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-19     Completed Date:  2009-10-09     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  101253260     Medline TA:  Curr Diabetes Rev     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Affiliation:
University of Queensland, Mater Clinical School, South Brisbane, QLD 4101, Australia. David.McIntyre@mater.org.au
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MeSH Terms
Descriptor/Qualifier:
Diabetes, Gestational / metabolism*
Female
Fetal Development*
Gene Expression Regulation, Developmental
Growth Hormone / metabolism*
Humans
Insulin-Like Growth Factor I / metabolism*
Placental Hormones / metabolism*
Pregnancy
Trophoblasts / metabolism
Chemical
Reg. No./Substance:
0/GH2 protein, human; 0/Placental Hormones; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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