Document Detail


Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome.
MedLine Citation:
PMID:  19844941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Placental growth hormone (PGH) is synthesised by the placenta, and its function is modulated by growth hormone binding protein (GHBP). The potential of PGH and GHBP as maternal serum screening markers for Down syndrome (DS) was examined. MATERIALS AND METHODS: Maternal serum concentrations of PGH and GHBP were determined by ELISA in 74 DS and 261 control pregnancies in gestational week 8(+0) to 13(+4). Log(10) MoM distributions of the markers were established. The performance of DS screening was estimated by Monte Carlo simulation. RESULTS: PGH log(10) MoM (SD) was decreased (p < 0.001) to -0.201 (0.373) and GHBP log(10) MoM to -0.116 (0.265) (p = 0.04), in DS pregnancies (n = 34) in week 8(+0) to 10(+0). In week 10(+1) to 13(+4), neither PGH (p = 0.16) nor GHBP (p = 0.13) was reduced in DS pregnancies. The detection rate (DR) for PGH in screening for DS in week 8(+0) to 10(+0) was 39% for a false positive rate (FPR) of 5%; increasing to 72% in combination with PAPP-A + hCGbeta. PGH + GHBP in combination with PAPP-A + hCGbeta + nuchal translucency (NT) (CUB test) had a DR of 91% compared with 80% for the CUB test. CONCLUSION: PGH and GHBP are early first trimester maternal serum markers for DS [Correction made here after initial online publication].
Authors:
Michael Christiansen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  29     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-10     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1249-55     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 John Wiley & Sons, Ltd.
Affiliation:
Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark. mic@ssi.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Carrier Proteins / blood*
Down Syndrome / blood*
Female
Fetal Diseases / blood*
Growth Hormone / blood*
Humans
Mass Screening
Placental Hormones / blood*
Pregnancy
Pregnancy Trimester, First
Prenatal Diagnosis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/GH2 protein, human; 0/Placental Hormones; 0/somatotropin-binding protein; 9002-72-6/Growth Hormone

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