Document Detail

Placental growth factor: a predictive marker for preeclampsia?
MedLine Citation:
PMID:  19346754     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An imbalance between angiogenic and antiangiogenic factors plays a fundamental role in the pathogenesis of preeclampsia. Serum levels of placental growth factor (PLGF), a factor promoting angiogenesis, in patients with preeclampsia are significantly lower than in nonpreeclamptic pregnancies. This study was designed to answer the question whether the measurement of PLGF at the beginning of the second trimester might be a predictive factor for the appearance of preeclampsia. METHODS: Serum samples of 61 women were collected between 15 and 18 weeks of pregnancy. PLGF levels were measured using a human PLGF ELISA and correlated with the outcomes of pregnancy. RESULTS: 7 women (11.47%) developed preeclampsia during pregnancy. Their PLGF levels between 15 and 18 weeks of pregnancy were significantly lower (p < 0.001) compared to the nonpreeclamptic pregnancies. Using a PLGF level of 41.84 pg/ml as a cutoff, this test has a sensitivity of 0.87 and a specificity of 0.83. CONCLUSION: Women who will develop preeclampsia in the course of pregnancy already have a significantly lower expression of PLGF between 15 and 18 weeks of pregnancy compared to those who will not. This test offers new possibilities in the prediction of preeclampsia.
Markus Schmidt; Canan Dogan; Cahit Birdir; Ulrich Kuhn; Alexandra Gellhaus; Rainer Kimmig; Sabine Kasimir-Bauer
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Publication Detail:
Type:  Journal Article     Date:  2009-03-25
Journal Detail:
Title:  Gynäkologisch-geburtshilfliche Rundschau     Volume:  49     ISSN:  1423-0011     ISO Abbreviation:  Gynakol Geburtshilfliche Rundsch     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-07     Revised Date:  2009-11-25    
Medline Journal Info:
Nlm Unique ID:  9212667     Medline TA:  Gynakol Geburtshilfliche Rundsch     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
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MeSH Terms
Biological Markers / blood
Pre-Eclampsia / blood*,  diagnosis*
Pregnancy Proteins / blood*
Pregnancy Trimester, First
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor

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