| Placental growth factor in the first trimester: relationship with maternal factors and placental Doppler studies. | |
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MedLine Citation:
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PMID: 20052659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Placental growth factor (PlGF) is a potent angiogenic factor that impacts on early placental vascular development. It was our aim to clarify relationships between PlGF and first-trimester maternal/placental factors that are related to placental development. METHODS: Prospectively enrolled patients at 11-14 weeks' gestation had serum PlGF measurement by enzyme-linked immunosorbent assay. Results were related to maternal age, parity, race, body mass index, mean arterial blood pressure (MAP), smoking/caffeine use and parameters of placental blood flow resistance. RESULTS: In 110 consecutive patients PlGF levels ranged between 1.0 and 176.1 pg/mL, showing a linear relationship with gestational age (GA) (PlGF = (1.4251 x GA) -74.951, r(2) = 0.0765, F = 8.941, P = 0.03). PlGF did not relate to maternal demographics but negatively correlated with MAP (Spearman rho = -0.191, P < 0.05). Bilateral uterine artery notching was associated with lower PlGF (40.7 (range, 1.01-131.6) vs. 51.1 (range, 6.4-176.1) pg/mL; Mann-Whitney P = 0.034.). A trend to lower levels was also observed when umbilical artery end-diastolic flow was absent (37.1 (range, 6.8-95) vs. 49.3 (range, 1.01-176.1) pg/mL; P = 0.05). CONCLUSION: PlGF in the first trimester is related to maternal cardiovascular factors and placental Doppler findings that are associated with subsequent placental dysfunction. The utility of this parameter as a first-trimester screening tool on a population basis requires further investigation. |
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Authors:
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T Kasdaglis; G Aberdeen; O Turan; J Kopelman; R Atlas; C Jenkins; M Blitzer; C Harman; A A Baschat |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Multicenter Study |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 35 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-09-16 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 280-5 Citation Subset: IM |
Copyright Information:
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(c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. tkasdaglis@upi.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Blood Pressure / physiology Body Mass Index Case-Control Studies Female Gestational Age Growth Hormone / blood* Humans Infant, Newborn Maternal Age Parity Placenta / blood supply, physiopathology*, ultrasonography Placental Hormones / blood* Placentation / physiology* Pregnancy Pregnancy Proteins / blood* Pregnancy Trimester, First Prospective Studies Vascular Resistance Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/GH2 protein, human; 0/Placental Hormones; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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