| Placental growth factor as a protective paracrine effector in the heart. | |
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MedLine Citation:
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PMID: 22902069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In response to injury, the myocardium hypertrophies in an attempt to maintain or augment function, which is associated with ventricular remodeling and changes in capillary density. During the compensatory phase of the hypertrophic response, the myocardium maintains output and is characterized by a coordinated neo-angiogenic and fibrotic response that supports cardiomyocyte health and survival. Emerging evidence shows that paracrine-mediated cross talk between cardiac myocytes and nonmyocytes within the heart is critical for cardiac adaptation to stress, including the extent of hypertrophy and angiogenesis. This review discusses recent results indicating that placental growth factor (PGF; also called PlGF), a secreted factor within the vascular endothelial growth factor superfamily, is a pivotal mediator of adaptive cardiac hypertrophy and beneficial angiogenesis through its ability to coordinate the intercellular communication between different cell types in the heart. |
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Authors:
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Federica Accornero; Jeffery D Molkentin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 21 ISSN: 1873-2615 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-08-20 Completed Date: 2013-01-11 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 220-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Division of Molecular Cardiovascular Biology and the Howard Hughes Medical Institute, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Cardiomegaly / metabolism*, pathology, physiopathology Humans Myocardium / metabolism*, pathology Neovascularization, Physiologic Paracrine Communication* Pregnancy Proteins / metabolism* Signal Transduction Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL062927/HL/NHLBI NIH HHS; R01 HL105924/HL/NHLBI NIH HHS; R37 HL060562/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Pregnancy Proteins; 144589-93-5/placenta growth factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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