Document Detail


Placental growth factor as a protective paracrine effector in the heart.
MedLine Citation:
PMID:  22902069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In response to injury, the myocardium hypertrophies in an attempt to maintain or augment function, which is associated with ventricular remodeling and changes in capillary density. During the compensatory phase of the hypertrophic response, the myocardium maintains output and is characterized by a coordinated neo-angiogenic and fibrotic response that supports cardiomyocyte health and survival. Emerging evidence shows that paracrine-mediated cross talk between cardiac myocytes and nonmyocytes within the heart is critical for cardiac adaptation to stress, including the extent of hypertrophy and angiogenesis. This review discusses recent results indicating that placental growth factor (PGF; also called PlGF), a secreted factor within the vascular endothelial growth factor superfamily, is a pivotal mediator of adaptive cardiac hypertrophy and beneficial angiogenesis through its ability to coordinate the intercellular communication between different cell types in the heart.
Authors:
Federica Accornero; Jeffery D Molkentin
Related Documents :
1798219 - Coronary artery spasm demonstrated by coronary angiography in a patient with acute myoc...
17700279 - Mr-relaxometry of myocardial tissue: significant elevation of t1 and t2 relaxation time...
9734489 - Clinical implications of the diagnosis of renal allograft infarction by percutaneous bi...
16880329 - Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevent...
2860699 - Cardiovascular manifestations of systemic lupus erythematosus: current perspective.
22203979 - Lethal arrhythmias in tbx3-deficient mice reveal extreme dosage sensitivity of cardiac ...
9420739 - Should all patients undergo cardiac catheterization after a myocardial infarction?
8817979 - Basic performance of a miniature intraventricular axial pump.
18412079 - What anti-thrombotic therapy is best with primary pci for acute st elevation myocardial...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Division of Molecular Cardiovascular Biology and the Howard Hughes Medical Institute, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Cardiomegaly / metabolism*,  pathology,  physiopathology
Humans
Myocardium / metabolism*,  pathology
Neovascularization, Physiologic
Paracrine Communication*
Pregnancy Proteins / metabolism*
Signal Transduction
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
R01 HL062927/HL/NHLBI NIH HHS; R01 HL105924/HL/NHLBI NIH HHS; R37 HL060562/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 144589-93-5/placenta growth factor
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Role of HCN Channels in Ventricular Repolarization.
Next Document:  p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defens...