Document Detail

Placental gene expression of transforming growth factor beta 1 (TGF-β1) in small for gestational age newborns.
MedLine Citation:
PMID:  25266958     Owner:  NLM     Status:  Publisher    
Abstract Objective: The gene expression of transforming growth factor beta-1 (TGF-β1) in human placental samples obtained from pregnancies with small for gestational age fetuses (SGA) was compared to those of normal pregnancies. Methods: In 2011 placental samples from 101 pregnancies with SGA and from 140 normal pregnancies were obtained for analysis of TGF-β1 gene expression. Several clinical parameters were also assessed for correlation between genetic and clinical parameters. Results: There were no significant differences in gene activity of the TGF-β1 gene between the SGA vs. normal pregnancy groups (Ln2(α): 0.16; p=0.07). Within the SGA group, no fetal gender-dependent differences were seen in TGF-β1 gene expression (Ln2(α): -0.11; p=0.05). Similarly, no significant differences in gene activity were observed by the degree of severity of SGA as assessed by percentile fetal birthweight (Ln2(α): 0.32; p=0.06). Conclusion: We found no change in gene expression of TGF-β1 in placental samples obtained from SGA pregnancies vs. normal pregnancy suggesting an absence of a direct role of the TGF-β1 gene in the development of SGA. However, the absence of increased gene expression of TGF-β1 in SGA can be conceptualized as a failure to mount a compensatory response in the SGA environment.
Attila Rab; Imre Szentpéteri; László Kornya; Balázs Börzsönyi; Csaba Demendi; Sándor Valent; Lajos Zsom; Hajnalka Hejja; József Gábor Joó
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-30
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-30     Completed Date:  -     Revised Date:  2014-10-1    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-14     Citation Subset:  -    
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