Document Detail

Placental and fetal Doppler velocimetry in pregnancies complicated by maternal diabetes mellitus.
MedLine Citation:
PMID:  8438946     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to investigate placental and fetal circulation in pregnancies complicated by maternal diabetes mellitus and to relate any changes to fetal blood pH, Po2, and hematocrit. STUDY DESIGN: Doppler measurements of both uterine arteries, one umbilical artery, the fetal descending thoracic aorta, and one fetal middle cerebral artery were performed in 65 well-controlled diabetic pregnancies in a cross-sectional study at the Harris Birthright Research Centre for Fetal Medicine, London. In 41 cases cordocentesis was also performed for the measurement of umbilical venous blood pH, Po2, and hematocrit. RESULTS: The mean umbilical venous blood pH was significantly lower and the hematocrit significantly higher than the appropriate normal mean for gestation. However, the Doppler indices of the placental and fetal circulations were essentially normal, except in some of the cases complicated by preeclampsia or intrauterine growth retardation. CONCLUSIONS: Maternal diabetes mellitus is not associated with abnormalities in Doppler indexes of the placental or fetal circulations.
D R Salvesen; M T Higueras; C A Mansur; J Freeman; J M Brudenell; K H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-22     Completed Date:  1993-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  AIM; IM    
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital School of Medicine, London, England.
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MeSH Terms
Blood Flow Velocity*
Blood Glucose / analysis
Fetal Blood
Fetus / physiology*
Hydrogen-Ion Concentration
Oxygen / blood
Placenta / blood supply*
Pregnancy in Diabetics / blood,  physiopathology*
Umbilical Veins
Reg. No./Substance:
0/Blood Glucose; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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