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Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia.
MedLine Citation:
PMID:  21585639     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Whitehead C, Palmer K, Nilsson U, Gao Y, Saglam B, Lappas M, Tong S. Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.02962.x. sFlt-1 is increased in the placenta and serum of women with pre-eclampsia. A novel primate-specific splice variant has recently been discovered, but its expression in severe pre-eclampsia has yet to be reported. We investigated placental expression of the previously described variant, sFlt-1/sFlt-i13, and the novel variant, sFlt-e15a, in pregnancies complicated by severe early onset pre-eclampsia (n = 14) and HELLP (haemolysis, elevated liver enzymes and a low platelet count) syndrome (n = 8). There was significant upregulation of both variants in pre-eclampsia and HELLP syndrome compared with normotensive term (n = 35) and preterm controls (n = 8). We conclude that the novel primate-specific splice variant of sFlt-1 is highly expressed in both severe pre-eclampsia and HELLP.
Authors:
Cl Whitehead; Kr Palmer; U Nilsson; Y Gao; B Saglam; M Lappas; S Tong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-18
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.
Affiliation:
 Translational Obstetrics Group, The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic., Australia  Department of Obstetrics and Gynaecology, Mercy Hospital, Melbourne University, Melbourne, Victoria, Australia  2nd Affiliated Hospital, Xi'an Jiatong, University School of Medicine, Xi'an, China.
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