Document Detail

Placental endoglin levels in diamniotic-monochorionic twin gestations: Correlation with clinical and placental characteristics.
MedLine Citation:
PMID:  23306069     Owner:  NLM     Status:  Publisher    
OBJECTIVE: While endoglin has been implicated in the pathogenesis of various complications in singleton pregnancies, its potential contribution to complications of monochorionic twinning remains largely undetermined. The aim of this study was to determine the correlation between relevant clinical and pathological variables and placental endoglin levels in diamniotic-monochorionic twin pregnancies. METHODS: Endoglin expression was studied by immunohistochemistry and Western blot in a prospective cohort of 68 non-TTTS and 7 TTTS monochorionic twin placentas. Placental endoglin levels were correlated with clinical and placental characteristics associated with twin-to-twin transfusion syndrome (TTTS) and selective growth restriction, including birth weight discordance, uneven placental sharing, peripheral cord insertion and choriovascular anatomy. RESULTS: In non-TTTS gestations discordant for these criteria, placental endoglin levels were significantly higher for the twin with smaller birth weight, intrauterine growth restriction, and/or abnormal ultrasound Doppler studies than for the more normal co-twin. Similarly, placental endoglin levels were significantly higher in the placental territory with smaller share and/or peripheral cord insertion in cases discordant for these placental characteristics. In TTTS gestations, placental endoglin levels tended to be higher for donor twins than for recipients. There was no correlation between endoglin levels and superficial choriovascular anastomoses. CONCLUSIONS: While the exact functional implications remain to be determined, our findings suggest a strong correlation between unbalanced placental endoglin levels and intertwin growth discordance in monochorionic twins.
S Chu; Q Mao; S Shapiro; M E De Paepe
Related Documents :
24331859 - Recent reproductive coercion and unintended pregnancy among female family planning clie...
12814049 - Massive unilateral hydrothorax as the only clinical manifestation of ovarian hyperstimu...
25035449 - Decidualised fallopian tube endometriotic implant causing spontaneous haemoperitoneum i...
19749679 - Laparoscopic lateral ovarian transposition: a fertility sparing procedure.
12959149 - Effect of ovarian cysts detected on the beginning day of ovulation induction to the suc...
21058449 - Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and rev...
7989509 - Teratozoospermia and in-vitro fertilization: a randomized prospective study.
6879679 - Hemolytic disease of the newborn following maternal self-injection of blood.
24274419 - Forty years of embryo transfer in cattle: a review focusing on the journal theriogenolo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Elsevier Trophoblast Research Award Lecture: Searching for an early pregnancy 3-D morphometric ultra...
Next Document:  Review: The role of autophagy in extravillous trophoblast function under hypoxia.