| Placental defects in alpha7 integrin null mice. | |
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MedLine Citation:
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PMID: 17904217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alpha7beta1 integrin is a heterodimeric transmembrane receptor that links laminin in the extracellular matrix to the cell cytoskeleton. Loss of the alpha7 integrin chain results in partial embryonic lethality. We have previously shown that alpha7 integrin null embryos exhibit vascular smooth muscle cell defects that result in cerebral vascular hemorrhaging. Since the placenta is highly vascularized, we hypothesized that placental vascular defects in alpha7 integrin null embryos may contribute to the partial embryonic lethality. Placentae from embryonic day (ED) 9.5 and 13.5 alpha7 integrin knockout embryos showed structural defects including infiltration of the spongiotrophoblast layer into the placental labyrinth, a reduction in the placental labyrinth and loss of distinct placental layers. Embryos and placentae that lacked the alpha7 integrin weighed less compared to wild-type controls. Blood vessels within the placental labyrinth of alpha7 integrin null embryos exhibited fewer differentiated vascular smooth muscle cells compared to wild-type. Loss of the alpha7 integrin resulted in altered extracellular matrix deposition and reduced expression of alpha5 integrin. Together our results confirm a role for the alpha7beta1 integrin in placental vascular development and demonstrate for the first time that loss of the alpha7 integrin results in placental defects. |
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Authors:
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J V Welser; N D Lange; N Flintoff-Dye; H R Burkin; D J Burkin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-09-27 |
Journal Detail:
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Title: Placenta Volume: 28 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-09-08 Revised Date: 2011-06-02 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 1219-28 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Nevada, Reno, NV 89557, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD / genetics*, metabolism Blotting, Western Endothelium, Vascular / metabolism, pathology Extracellular Matrix / metabolism, pathology Female Fetal Death / genetics Fetal Weight / genetics Immunohistochemistry Integrin alpha Chains / deficiency*, genetics*, metabolism Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular / pathology Placenta / blood supply*, growth & development, pathology Placenta Diseases / genetics*, pathology Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR015581-059004/RR/NCRR NIH HHS; P20 RR015581-069004/RR/NCRR NIH HHS; P20 RR015581-076560/RR/NCRR NIH HHS; P20 RR018751-01/RR/NCRR NIH HHS; P20 RR018751-010001/RR/NCRR NIH HHS; P20 RR018751-020001/RR/NCRR NIH HHS; P20 RR018751-030001/RR/NCRR NIH HHS; P20 RR018751-035832/RR/NCRR NIH HHS; P20 RR018751-047407/RR/NCRR NIH HHS; P20 RR15581-04/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Integrin alpha Chains; 0/integrin alpha7 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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