Document Detail


Placental cytokine expression covaries with maternal asthma severity and fetal sex.
MedLine Citation:
PMID:  19155488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the presence of maternal asthma, we have previously reported reduced placental blood flow, decreased cortisol metabolism, and reductions in fetal growth in response to maternal asthma and asthma exacerbations. We have proposed that these changes in placental function and fetal development may be related to activation of proinflammatory pathways in the placenta in response to maternal asthma. In the present study, we examined the influence of maternal asthma severity, inhaled glucocorticoid treatment, maternal cigarette use, placental macrophage numbers, and fetal sex on placental cytokine mRNA expression from a prospective cohort study of pregnant women with and without asthma. Placental expression of TNF-alpha, IL-1beta, IL-6, IL-8, and IL-5 mRNA were all increased significantly in placentae of female fetuses whose mothers had mild asthma, but no changes were observed in placentae of male fetuses. The proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were negatively correlated with female cord blood cortisol, but there were no such correlations in placentae from males. Multivariate analysis indicated the strongest predictor of both cytokine mRNA expression in the placenta and birth weight was fetal cortisol but only in females. Placental cytokine mRNA levels were not significantly altered by inhaled glucocorticoid use, placental macrophage numbers, cigarette use, moderate-severe asthma, or male sex. These data suggest that placental basal cytokine mRNA expression is sex specifically regulated in pregnancies complicated by asthma, and interestingly these changes are more prevalent in mild rather than severe asthma.
Authors:
Naomi M Scott; Nicolette A Hodyl; Vanessa E Murphy; Annette Osei-Kumah; Hayley Wyper; Deborah M Hodgson; Roger Smith; Vicki L Clifton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  182     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1411-20     Citation Subset:  AIM; IM    
Affiliation:
Mothers and Babies Research Centre, Newcastle, New South Wales, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Asthma / drug therapy,  immunology*,  pathology,  physiopathology
Birth Weight / immunology
Cytokines / biosynthesis*,  genetics
Female
Glucocorticoids / therapeutic use
Leukocyte Count
Macrophages / pathology
Maternal-Fetal Exchange / immunology*
Pregnancy
Pregnancy Complications / drug therapy,  immunology*,  pathology,  physiopathology
Pregnancy Proteins / biosynthesis*,  genetics
RNA, Messenger / biosynthesis
Rats
Severity of Illness Index
Sex Characteristics*
Smoking / immunology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Glucocorticoids; 0/Pregnancy Proteins; 0/RNA, Messenger

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