Document Detail


Placental corticotropin-releasing factor. An update.
MedLine Citation:
PMID:  10818395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticotropin-releasing factor (CRF) produced in placenta has paracrine effects within placenta, decidua, and myometrium and endocrine effects on mother and fetus. CRF is a potent local regulator of myometrial contractility and of prostaglandin release, Recently, urocortin, a new member of the CRF family, has been localized in human placenta and membranes. Urocortin mimics some of the local effects of CRF in intrauterine tissues, that is, increase of adrenocorticotrophic hormone (ACTH) and prostagiandin release and myometrial contractility. A local CRF-BP modulates the paracrine effects of CRF and urocortin. The various CRF receptor subtypes are well distributed in placenta and membranes. CRH also acts on placental blood vasculature and has an action on fetal adrenal gland to stimulate the production of the steroid DHEA-S. In nonpregnant women, plasma CRF levels are low; they become higher during the first and second trimesters of pregnancy. A clear increase is evident at term and when CRF-BP levels decrease. Women with preterm labor show high CRF and low CRF-BP levels, supporting an involvement of this pathway in mechanism of parturition.
Authors:
M Fadalti; I Pezzani; L Cobellis; F Springolo; M M Petrovec; G Ambrosini; F M Reis; F Petraglia
Related Documents :
7270095 - The implication of a low implantation of the placenta detected by ultrasonography in ea...
3204265 - Effects of histamine on vascular resistance and protein permeability in the isolated du...
24983755 - Quantifying low birth weight, preterm birth and small-for-gestational-age effects of ma...
8515685 - Placental transfer of (3h)-gm1 and its distribution to maternal and fetal tissues of th...
18022165 - Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retri...
22965365 - Association between maternal and fetal weight gain: cohort study.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  900     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2000  
Date Detail:
Created Date:  2000-06-01     Completed Date:  2000-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Affiliation:
Department of Surgical Sciences, Obstetrics and Gynecology, University of Udine, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Corticotropin-Releasing Hormone / biosynthesis,  physiology*
Female
Humans
Labor, Obstetric / physiology
Placenta / metabolism*
Pregnancy
Urocortins
Uterus / physiology
Chemical
Reg. No./Substance:
0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thyroidopathies.
Next Document:  Maternal hypothalamic-pituitary-adrenal axis in pregnancy and the postpartum period. Postpartum-rela...