| Placental corticotrophin-releasing hormone, local effects and fetomaternal endocrinology. | |
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MedLine Citation:
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PMID: 22432143 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The human placenta produces corticotrophin-releasing hormone (CRH) in exponentially increasing amounts during pregnancy with peak levels during labour. CRH in human pregnancy appears to be involved in many aspects of pregnancy including placental bloodflow, placental prostaglandin production, myornetrial function, fetal pituitary and adrenal function and the maternal stress axis. Since fetal cortisol levels are associated with pulmonary development and maturity, placental CRH may have an indirect role in fetal development.Although the precise role of placental CRH in the regulation of gestational length and timing of parturition is unclear it appears to be involved in a placental clock. While glucocorticoids inhibit hypothalamic CRH production they stimulate CRH gene expression in the placenta.This difference may allow the fetal and maternal stress axes to influence this placental clock.Maternal CRH levels are elevated in many pathological conditions of pregnancy where fetal well-being is compromised, and in these situations it may act to maintain a stable intrauterine environment. Therefore, CRH appears to link placental function, maternal well-being, fetal well-being and fetal development to the duration of gestation and the timing of parturition. |
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Authors:
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B R King; R C Nicholson; R Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Stress (Amsterdam, Netherlands) Volume: 4 ISSN: 1025-3890 ISO Abbreviation: Stress Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2012-03-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9617529 Medline TA: Stress Country: England |
Other Details:
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Languages: eng Pagination: 219-33 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Mothers and Babies Research Centre, John Hunter Hospital & University of Newcastle, Locked Bag No. I , Hunter region mail centre, Newcastle, NSW 2310, Australia. rndrsm@mail.newcastle.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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