Document Detail


Placental corticotrophin-releasing hormone and its receptors in human pregnancy and labour: still a scientific enigma.
MedLine Citation:
PMID:  18266947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is now accepted that, in humans, placental corticotrophin-releasing hormone (CRH) is involved in the mechanisms controlling the onset of labour; however, the precise biological role in foeto-maternal tissues remain enigmatic. Maternal plasma levels of CRH rise exponentially as pregnancy progresses towards term and peak during labour; however, evidence to link this with an active role in the onset and progression of labour, is still inconclusive. Certainly, one of the tissues targeted by CRH is the myometrial smooth muscle, which expresses a plethora of specific CRH receptors. This finding implicates CRH in the mechanisms preparing the myometrial microenvironment for the onset of labour and possibly in the regulation of active contractility during labour. Other gestational tissues also targeted by CRH include the placenta, foetal membranes and foetal adrenals, where CRH might regulate distinct physiological functions, ranging from control of vascular tone to adrenal steroidogenesis and prostaglandin synthesis and activity. Given the unique, among mammals, pattern of human placental CRH secretion and CRH receptor expression and signalling during pregnancy and labour, there are only limited biological tools available to delineate the actions of CRH in foeto-maternal tissues, primarily based on in vitro characterisation of the signalling and molecular events driven by CRH. This review will set in context the current concepts about the role of CRH and its receptors during pregnancy and labour, focusing on the unresolved questions and paradoxes that currently exist.
Authors:
D K Grammatopoulos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-08
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  20     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  432-8     Citation Subset:  IM    
Affiliation:
Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, UK. d.grammatopoulos@warwick.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Corticotropin-Releasing Hormone / metabolism,  physiology*
Extraembryonic Membranes / metabolism
Female
Humans
Labor, Obstetric / physiology*
Models, Biological
Myometrium / metabolism
Placenta / metabolism*,  physiology
Pregnancy / physiology*
Receptors, Corticotropin-Releasing Hormone / metabolism,  physiology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Receptors, Corticotropin-Releasing Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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