Document Detail


Placental contribution to lactate production by the human fetoplacental unit.
MedLine Citation:
PMID:  6518068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Umbilical cord blood levels of lactate, base deficit, and pH were measured in 452 liveborn infants. In vigorous newborns, the mean umbilical arterial and venous concentrations of lactate were lowest with elective cesarean section, higher with cesarean section performed during labor, and highest with vaginal delivery (P less than .001). This suggests a rise in the fetal lactate level in response to labor. However, there was no concomitant increase in the mean umbilical arteriovenous lactate differences, indicating that both fetus and placenta increase their lactate production proportionately with labor. Depressed newborns had higher umbilical lactate levels than vigorous newborns irrespective of the method of delivery (P less than .001). Depressed newborns also had a higher mean umbilical arteriovenous lactate difference than vigorous newborns (P less than .001). This suggests that, under conditions that lead to neonatal depression, the fetus is the major source of the increased lactate produced, with a smaller contribution from the placenta. The fetal lactate level may be a good indicator of fetal stress in labor.
Authors:
J S Suidan; J F Wasserman; B K Young
Related Documents :
8677088 - Pharmacologic treatment of psychiatric disease in pregnancy and lactation: fetal and ne...
7548178 - Expression of fatty acid binding protein in the liver during pregnancy and lactation in...
9582548 - Omeprazole for refractory gastroesophageal reflux disease during pregnancy and lactation.
23337718 - Maternal obesity is associated with the formation of small dense ldl and hypoadiponecti...
22854118 - Neonatal morbidity in growth-discordant monochorionic twins: comparison between the lar...
462418 - Effect of factor xii deficiency on pregnancy and parturition.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  1     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1985-03-21     Completed Date:  1985-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism
Cesarean Section
Female
Fetal Blood
Fetus / metabolism*
Humans
Hydrogen-Ion Concentration
Infant, Newborn
Labor, Obstetric
Lactates / blood*
Maternal-Fetal Exchange
Placenta / metabolism*
Pregnancy
Umbilical Arteries
Umbilical Veins
Chemical
Reg. No./Substance:
0/Lactates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maternal lithium and neonatal Ebstein's anomaly: evaluation with cross-sectional echocardiography.
Next Document:  The placental transfer of ampicillin.