Document Detail

Placental contribution to lactate production by the human fetoplacental unit.
MedLine Citation:
PMID:  6518068     Owner:  NLM     Status:  MEDLINE    
Umbilical cord blood levels of lactate, base deficit, and pH were measured in 452 liveborn infants. In vigorous newborns, the mean umbilical arterial and venous concentrations of lactate were lowest with elective cesarean section, higher with cesarean section performed during labor, and highest with vaginal delivery (P less than .001). This suggests a rise in the fetal lactate level in response to labor. However, there was no concomitant increase in the mean umbilical arteriovenous lactate differences, indicating that both fetus and placenta increase their lactate production proportionately with labor. Depressed newborns had higher umbilical lactate levels than vigorous newborns irrespective of the method of delivery (P less than .001). Depressed newborns also had a higher mean umbilical arteriovenous lactate difference than vigorous newborns (P less than .001). This suggests that, under conditions that lead to neonatal depression, the fetus is the major source of the increased lactate produced, with a smaller contribution from the placenta. The fetal lactate level may be a good indicator of fetal stress in labor.
J S Suidan; J F Wasserman; B K Young
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  1     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1985-03-21     Completed Date:  1985-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
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MeSH Terms
Acidosis / metabolism
Cesarean Section
Fetal Blood
Fetus / metabolism*
Hydrogen-Ion Concentration
Infant, Newborn
Labor, Obstetric
Lactates / blood*
Maternal-Fetal Exchange
Placenta / metabolism*
Umbilical Arteries
Umbilical Veins
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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