| Placental calcium transport during acute maternal hypermagnesemia in the rat. | |
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MedLine Citation:
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PMID: 8456913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our aim was to test the hypothesis that maternofetal placental calcium transfer rate decreases in experimentally induced acute maternal hypermagnesemia in the rat. STUDY DESIGN: We measured the unidirectional maternofetal clearance of calcium 45 and chromium 51-ethylenediaminetetraacetic acid across in situ perfused placentas of rats randomized to intravenous treatment with saline solution and magnesium sulfate (n = 5) or to saline solution only (n = 5) before placental perfusion. The maternofetal clearance of chromium 51-ethylenediaminetetraacetic acid provides a measure of placental "porosity" or passive permeability. RESULTS: The mean serum magnesium concentration increased to 5.3 +/- 0.6 mg/dl (2.18 +/- 0.25 mmol/L) in magnesium-infused rats, staying at 1.8 +/- 0.1 mg/dl (0.74 +/- 0.04 mmol/L) in control rats (p < 0.001). Neither the maternofetal clearance of calcium 45 nor that of chromium 51-ethylenediaminetetraacetic acid was affected by acute maternal hypermagnesemia. CONCLUSION: Within the range of hypermagnesemia studied, placental calcium transport remains unaffected. |
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Authors:
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F Mimouni; Z Mughal; G Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 168 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-16 Completed Date: 1993-04-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 984-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Pittsburgh School of Medicine, PA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Calcium / metabolism* Calcium Radioisotopes Chromium Radioisotopes Edetic Acid Female Hydrogen-Ion Concentration Magnesium / blood* Maternal-Fetal Exchange* Placenta / metabolism* Pregnancy Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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HD-11725/HD/NICHD NIH HHS; HD-20748/HD/NICHD NIH HHS; RR00068/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Radioisotopes; 0/Chromium Radioisotopes; 60-00-4/Edetic Acid; 7439-95-4/Magnesium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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