Document Detail

Placental calcification in pseudoxanthoma elasticum.
MedLine Citation:
PMID:  18695775     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Pseudoxanthoma elasticum (PXE) is an inherited multisystem disorder of the elastic tissue and the objective of this case report is to correlate ultrasonographic and histological appearances of placental calcification in PXE. CLINICAL PICTURE: We report a case of a 37-year-old white woman with PXE, whose antenatal imaging showed a markedly echogenic placenta due to extensive calcification confirmed on postpartum placental histology. OUTCOME: There were no maternal or fetal complications in the antenatal period. A healthy baby of appropriate maturity and weight was delivered via Caesarean section and remained well at 6 months. CONCLUSION: The majority of cases of PXE is caused by mutations in the ABCC6 gene. Serious complications in pregnancy can include gastrointestinal haemorrhage, congestive heart failure and cardiac arrhythmia but has not been shown to be associated with markedly increased fetal loss or adverse reproductive outcomes as reported in previous literature. Apart from the cosmetic deterioration of the abdominal skin, there were few serious complications and most have normal pregnancies. Obstetric prognosis is dependent on the vascular damage caused by the illness. There is no basis for advising women with PXE to avoid becoming pregnant, and most pregnancies in PXE are uncomplicated.
Wei Ching Tan; Charles H Rodeck
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  37     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  598-600     Citation Subset:  IM    
Department of Obsterics and Gynaecology, Singapore General Hospital, Singapore.
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MeSH Terms
Calcinosis / diagnosis,  etiology*
Cesarean Section
Placenta Diseases / diagnosis*,  etiology*,  pathology
Pregnancy Outcome
Pseudoxanthoma Elasticum / complications*,  diagnosis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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