Document Detail

Placental biopsy by frozen section: does it have a role in evaluation of fetal well-being?
MedLine Citation:
PMID:  14712946     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the effectiveness of post-partum placental biopsy and frozen section evaluation in diagnosing pregnancy disorders. STUDY DESIGN: Between January and July 1998, biopsies were carried out on 100 newly delivered placentas. Biopsies were carried out using a 14-gauge needle, and frozen section evaluations were reviewed. These were compared to the standard evaluation of histological evaluation of the whole placenta sections. Specimens were evaluated by standard placental pathologic criteria. RESULTS: Villous oedema which is associated with antenatal hypoxia was observed with a sensitivity of 78%, and specificity of 97%, yielding a positive predictive value of 84% in frozen section compared to standard placental evaluation. No statistical difference was observed in the evaluation of dysmaturity, intravillous fibrin agglutination and chronic villitis between frozen sectioning and whole placenta sections. Increased syncytial knots were detected with a sensitivity of 45% and specificity of 98%. CONCLUSION: Placental biopsy by frozen sectioning might be a useful and quick method of evaluation for placental pathology. Theoretically, fetal status could be more precisely evaluated by combining prenatal placental biopsy by permanent section with conservative ante-partum well-being tests.
Inanc Mendilcioglu; Bahar Kilicarslan; Cahit Gurkan Zorlu; Seyda Karaveli; Mine Uner; Bilal Trak
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  43     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-09     Completed Date:  2004-03-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Medical School, Akdeniz University, Arapsuyu, Antalya, Turkey.
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MeSH Terms
Biopsy / methods,  standards
Frozen Sections
Placenta / pathology*
Postpartum Period
Predictive Value of Tests
Pregnancy Complications / diagnosis*
Prenatal Diagnosis / standards*
Retrospective Studies
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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