Document Detail

Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae.
MedLine Citation:
PMID:  21388889     Owner:  NLM     Status:  MEDLINE    
Failure of physiologic transformation of the spiral arteries has been studied using placental bed biopsies in several obstetrical syndromes. Contrary to what was originally believed, this lesion is not restricted to preeclampsia and/or intrauterine growth restriction. A review of published evidence indicates that failure of physiologic transformation can be observed in women with spontaneous second trimester abortions, preterm labor with intact membranes, preterm prelabor rupture of membranes and abruptio placentae. Therefore, disorders of deep placentation are present in a wide range of complications of pregnancy, emphasizing the importance of understanding the physiology and pathology of transformation of the spiral arteries. We propose that changes in the population and function of immunocytes at the maternal-fetal interface can be part of the mechanism of disease of obstetrical disorders, and this requires further investigation.
Roberto Romero; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Sonia S Hassan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2011-03-08
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  25     ISSN:  1532-1932     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-09-06     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-27     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA.
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MeSH Terms
Abortion, Spontaneous / physiopathology*
Abruptio Placentae / physiopathology*
Fetal Membranes, Premature Rupture / physiopathology*
Obstetric Labor, Premature / physiopathology*
Placenta / blood supply,  physiopathology
Placenta Diseases / physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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