Document Detail

Placental basal plate formation is associated with fibrin deposition in decidual veins at sites of trophoblast cell invasion.
MedLine Citation:
PMID:  11854653     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We hypothesize that placenta growth and basal plate (Nitabuch's fibrinoid) formation involves fibrin deposition in decidual veins as trophoblast cells invade. STUDY DESIGN: Decidua from women who underwent first trimester elective pregnancy termination (n = 15 women), in situ pregnancy (n = 2 women), and ectopic pregnancy (n = 5 women) were immunostained with polyclonal antibodies to fibrin. Serial sections of decidua were studied with monoclonal antibodies to oncofetal fibronectin, cytokeratin, and Factor VIII-related antigen. RESULTS: In all intrauterine pregnancies, trophoblast cells were identified with clots in decidual veins. Fibrin and oncofetal fibronectin were present in veins at sites of trophoblast cell invasion and in the developing basal plate matrix where villi had implanted into veins. Fibrin deposits were not seen in decidual parietalis of ectopic or in situ pregnancies. CONCLUSION: We have identified fibrin in decidual veins that is associated with trophoblast cell invasion. We speculate that the formation of basal plate protein (Nitabuch's fibrinoid) involves these intravenous fibrin deposits.
Catherine M Craven; Lisa R Chedwick; Ken Ward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-20     Completed Date:  2002-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  AIM; IM    
EmerGen, Salt Lake City, UT 84108, USA.
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MeSH Terms
Abortion, Induced
Decidua / blood supply*
Fibrin / metabolism*
Placenta / physiology*,  physiopathology
Placental Circulation*
Pregnancy Trimester, First
Pregnancy, Ectopic / physiopathology
Reference Values
Trophoblasts / physiology*
Veins / metabolism
Grant Support
1R01-HD 32170-01/HD/NICHD NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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