Document Detail


Placental apoptosis in discordant twins.
MedLine Citation:
PMID:  11969344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate placental apoptosis in discordant dichorial twins. METHODS: Placental samples were obtained from 7 third-trimester suitable twins. Discordancy was defined as a >25 per cent difference in newborn birth weight. Light microscopy using hematoxylin and eosin (H&E)-stained paraffin slides and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labelling (TUNEL) methods were used to confirm the incidence of apoptosis. Investigators were blinded to pregnancy outcome. RESULTS: Both methods revealed that the incidence of apoptosis in the placentas of the smaller fetuses was significantly higher than in placentas of the larger fetuses. The incidence of TUNEL-positive cells in the former was 1.4+/-0.26 per cent: this was significantly higher than the incidence of apoptosis in the placental specimens of the latter (0.9+/-0.07 per cent, P< 0.02 Wilcoxon rank test). The same results were obtained with H&E: the incidence of apoptosis detected in placentas from the former was 1.07+/-0.1 per cent compared to 0.72+/-0.08 per cent in those of the latter (P< 0.02 Wilcoxon rank test). CONCLUSIONS: Despite similar environment conditions, placental apoptosis is increased in the smaller fetus and thus might play a role in discordancy between twins. Since increased placental apoptosis has also been found in singleton intrauterine growth restriction, this supports the hypothesis that the smaller twin is selectively growth restricted.
Authors:
B Almog; O Fainaru; R Gamzu; M J Kupferminc; R Sasson; R Gold; J B Lessing; A Amsterdam; A Many
Related Documents :
1565394 - Exclusion of monoamniotic twinning by contrast-enhanced computed tomography.
15703534 - Folate supplementation and twin pregnancies.
20381424 - Blood-borne angiogenic factors and sustained multiple implantation: a comparison of sin...
16761544 - Successful treatment of brucellosis in a twin pregnancy.
17459564 - Re-evaluation of the indication for and limitation of laparoscopic salpingotomy for tub...
7778824 - Cardiovascular problems in pregnant women with the marfan syndrome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  23     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-23     Completed Date:  2002-11-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. beny118@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis*
Birth Weight
Diseases in Twins*
Female
Fetal Growth Retardation / pathology*
Humans
In Situ Nick-End Labeling
Infant, Newborn
Organ Size
Placenta / pathology*
Pregnancy
Pregnancy, Multiple
Twins, Dizygotic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Growth factor rescue of cytokine mediated trophoblast apoptosis.
Next Document:  Placental pathology in early onset pre-eclampsia and intra-uterine growth restriction in women with ...