| Placental alkaline phosphatase as the placental IgG receptor. | |
| | |
MedLine Citation:
|
PMID: 1458596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We review data from our studies of the physiological role of placental alkaline phosphatase (PLAP) and report that, in addition to functioning in catalysis, PLAP has the capacity to bind the Fc portion of human IgG. The dissociation constant for the interaction (3.86 mumol/L) indicates that the PLAP-IgG complex probably occurs in vivo. Furthermore, the electrophoretic and immunochemical properties of PLAP are identical to those of the purified placental Fc receptor. This receptor is believed to participate in the transfer of IgG molecules from the maternal circulation to the fetus during pregnancy. Studies with HEp2 cells show that PLAP is necessary for the internalization of IgG molecules. PLAP behaves, at least in this cell line, as an Fc receptor. The presence of large amounts of PLAP in clathrin-coated vesicles prepared from placenta strongly indicates that PLAP is involved in the endocytic machinery in this organ. We conclude that these results, taken together, suggest a novel biological role for PLAP. |
| | |
Authors:
|
R Makiya; T Stigbrand |
Related Documents
:
|
2797636 - Placental isoferritin measured by a specific monoclonal antibody as a predictive marker... 19876826 - On the role of placental major histocompatibility complex and decidual leukocytes in im... 21548016 - Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. 9802186 - Pharmacokinetic studies of enalaprilat in the in vitro perfused human placental lobule ... 1505386 - Insulinoma in pregnancy presenting as a seizure disorder: a case report. 19252776 - Pregnancy and epilepsy: what should we tell our patients? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Clinical chemistry Volume: 38 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1992 Dec |
Date Detail:
|
Created Date: 1993-01-14 Completed Date: 1993-01-14 Revised Date: 2010-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2543-5 Citation Subset: IM |
Affiliation:
|
Department of Medical Biochemistry and Biophysics, University of Ume?, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkaline Phosphatase
/
chemistry,
metabolism* Amino Acid Sequence Coated Pits, Cell-Membrane / enzymology Female Humans Immunoglobulin G / metabolism* Isoenzymes / chemistry, metabolism* Molecular Sequence Data Placenta / enzymology*, immunology Receptors, IgG / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 0/Isoenzymes; 0/Receptors, IgG; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.1/alkaline phosphatase, placental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemical nature of intestinal-type alkaline phosphatase in human kidney.
Next Document: Alkaline phosphatase isoenzyme patterns in malignant disease.