Document Detail

Placental agenesis, embryonal hydraemia, embryolethality and acute hypervitaminosis A in rats.
MedLine Citation:
PMID:  999789     Owner:  NLM     Status:  MEDLINE    
Acute maternal hypervitaminosis A established on Day 9 of gestation in Sprague-Dawley-derived rats caused a dose-related increase in the resorption of implants. The median embryolethal dose was 189,000 i.u./kg. In addition to suppression of the allantois leading to placental agenesis, damaged embryos showed retarded somatic development and hydraemia, all apparent 24 h after treatment. At about Day 11 the hydraemia involved the visceral wall of the yolk sac causing death of the embryo soon after. The fluid in the vitelline vessels continued to collect until Day 13 when it absorbed following necrosis of the wall of the yolk sac. Two mechanisms are suggested for the embryonal hydraemia: either the excess fluid resulted from a permeability disorder induced by the vitamin A; or it was retained metabolic water or water specifically absorbed to inflate the allantois and, being unused for this purpose, it pooled in the blood vessels of the embryo. The yolk sac hydraemia is more likely to have followed injury to the proximal endoderm.
A M Love; T H Vickers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  57     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-41     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced
Allantois / ultrastructure
Dose-Response Relationship, Drug
Embryo Loss / chemically induced*
Embryo, Mammalian / ultrastructure
Fetal Death / chemically induced*
Microscopy, Electron, Scanning
Placenta Diseases / chemically induced*
Time Factors
Vitamin A / toxicity*
Vitelline Membrane / ultrastructure
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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