Document Detail

Placental abnormalities and preeclampsia in trisomy 13 pregnancies.
MedLine Citation:
PMID:  19346185     Owner:  NLM     Status:  MEDLINE    
Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.
Chih-Ping Chen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  48     ISSN:  1875-6263     ISO Abbreviation:  -     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Cell Adhesion Molecules / genetics
Chromosomes, Human, Pair 13 / genetics*
Collagen Type IV / genetics
Placenta Diseases*
Pre-Eclampsia / genetics*
Vascular Endothelial Growth Factor Receptor-1 / genetics
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Collagen Type IV; 0/POSTN protein, human; EC protein, human; EC Endothelial Growth Factor Receptor-1

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