Document Detail


Placental abnormalities in systemic lupus erythematosus: in situ deposition of antinuclear antibodies.
MedLine Citation:
PMID:  2963129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 5 placentae from patients with systemic lupus erythematosus (SLE) for the presence of immunopathologic changes. We found antinuclear antibodies (ANA) deposited along the villi, trophoblast and amnion producing a lupus band-like pattern. The ANA were IgG class and had C3 fixing activity. Of the T cell subsets found in the placenta, OKT8 was the predominant type in patients with SLE and controls. All the patients were ANA positive, and 1 was also positive for anti-Ro(SSA). One newborn, positive for ANA and anti-Ro(SSA), developed neonatal lupus, 1 infant with a cardiac septal defect was ANA negative, and the other infants were normal. Our study demonstrates that in pregnant women with SLE, ANA deposition occurs in the placenta in situ.
Authors:
L Guzman; E Avalos; R Ortiz; R Gurrola; E Lopez; R Herrera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  14     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-02     Completed Date:  1988-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  924-9     Citation Subset:  IM    
Affiliation:
Department of Immunology, Universidad Autonoma de Zacatecas, School of Medicine, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / analysis*
Chorionic Villi / pathology
Female
Fluorescent Antibody Technique
Humans
Immune Complex Diseases / pathology*
Immunoenzyme Techniques
Infant, Newborn
Lupus Erythematosus, Systemic / pathology*
Placenta / pathology*
Pregnancy
Pregnancy Complications / pathology*
T-Lymphocytes / pathology
Trophoblasts / pathology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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