| Placental Villous Hypermaturation is Associated with Idiopathic Preterm Birth. | |
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MedLine Citation:
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PMID: 23130816 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: Pregnancy complications such as intra-amniotic infection, preeclampsia, and fetal growth restriction (IUGR) account for most cases of preterm birth (PTB), but many spontaneous PTB cases do not have a clear etiology. We hypothesize that placental insufficiency may be a potential cause of idiopathic PTB. Methods: Secondary analysis of 82 placental samples from women with PTB obtained from a multicenter trial of repeat vs single antenatal corticosteroids. Samples were centrally reviewed by a single placental pathologist masked to clinical outcomes. The histopathologic criterion for infection was the presence of acute chorioamnionitis defined as neutrophils marginating into the chorionic plate. Placental villous hypermaturation (PVH) was defined as a predominance of terminal villi (similar to term placenta) with extensive syncytial knotting. Idiopathic PTB comprised a group without another known etiology such as preeclampsia, IUGR, or infection. Results: Acute chorioamnionitis was observed in 33/82 (40%) cases. Other known causes of PTB were reported in 18/82 (22%). The remaining 31/82 (38%) were idiopathic. The frequency of PVH in idiopathic PTB (26/31=84%) was similar to cases with IUGR or preeclampsia (16/18=89%), but significantly more common than PVH in the group with acute chorioamnionitis (10/33=30%) (P<0.001). Conclusions: Placental villous hypermaturation, which is a histologic marker of relative placental insufficiency, is a common finding in idiopathic PTB. |
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Authors:
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Terry K Morgan; Jorge E Tolosa; Lisa Mele; Ronald J Wapner; Catherine Y Spong; Yoram Sorokin; Donald J Dudley; Alan M Peaceman; Brian M Mercer; John M Thorp; Mary Jo O'Sullivan; Susan M Ramin; Dwight J Rouse; Baha Sibai; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-6 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of 1Obstetrics & Gynecology and 2Pathology, Oregon Health & Science University. Portland, Oregon; and from the Department of Obstetrics and Gynecology of Columbia University (RJW), Wayne State University, Detroit, MI (YS), University of Utah, Salt Lake City, UT (DJD), Northwestern University, Chicago, IL (AMP), Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH (BMM), University of North Carolina at Chapel Hill, Chapel Hill, NC (JMT), University of Miami, Miami, FL (MJO), The University of Texas Health Science Center at Houston, Houston, TX (SMR), University of Alabama at Birmingham, Birmingham, AL (DJR), University of Tennessee, Memphis, TN (BS), and The George Washington University Biostatistics Center, Washington, DC (LM) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (CYS). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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